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Optimization strategies for combination therapies The optimization of combination therapies should be guided by three synergistic principles: complementary metabolic pathway targeting, spatiotemporal coordination, and metabolic-immune crosstalk regulation

Given the role of NAD + in modulating the processes described above, NAD + -boosting interventions are being investigated for supporting mitochondrial homeostasis

This leads to inefficient energy generation and heightens the likelihood of neuronal degeneration

Selenium supplementation was done by first mixing the Se-methionine (Sel-Plex, Alltech Inc., Nicholasville, KY, USA) with 100 g of the diet, then thoroughly blending it into the remaining feed to ensure uniform distribution

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