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3) in line with previous studies [20, 33], and infusion of insulin receptor antagonist S961 neither affected basal nor glucose- or arginine-stimulated somatostatin secretion

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in fact, some rats engaged in motivated lever press behavior very little (low responders), while others did much more (high responders), suggesting differential DA system involvement

This impairment compromises mitochondrial ATP production, resulting in cellular energy deficits (Siddiqui et al., 2016)