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This action of CHAC1 aligns with its regulation by transcription factors ATF4 and ATF3, suggesting a tightly controlled mechanism whereby CHAC1 contributes to the cellular apoptosis process, particularly in stress responses ( 4.5 Ferroptosis Ferroptosis is a regulated form of cell death characterized by the accumulation of lipid peroxides, particularly in membrane phospholipids, which occurs when the cellular antioxidant defense is insufficient

10.1007/s40618-015-0337-0 57

Consistent with this, TCA cycle intermediate labeling patterns revealed that ACT impairs mitochondrial glucose oxidation in WT cells, while loss of ATP6AP1 partially restores this capacity

Strategies for inhibition and disaggregation of amyloid- fibrillation

ICSI in cases of sperm DNA damage: beneficial effect of oral antioxidant treatment