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Description

The mitochondrial DNA concentration in the skeletal muscles of healthy subjects also decreases if they perform intense exercise, but because the gene that encodes peroxisome proliferators-activated receptor-coactivator-1a (PGC-1a), which is involved in mitochondrial energy production during high-intensity exercise, is overexpressed in COPD patients, excessive production of active oxygen species as a result of intense exercise may be the reason for the decrease in mitochondrial DNA [33]