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(2018) reported three patients had a mild to moderate increase in tremor, one of whom led to discontinuation from the study

Second, ROS and mitochondrial DNA (mtDNA), as damage-associated molecular patterns (DAMPs), along with pathogen-associated molecular patterns (PAMPs), may activate the NLRP3 inflammasome and induce the release of pro-inflammatory cytokines such as IL-1, IL-6, and TNF-, potentially transforming localized metabolic stress into a systemic inflammatory response

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Approximately 20 mg of dried CFS was subjected to transesterification using 0.5 N methanolic KOH (2.805 g KOH in 100 mL methanol)