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4 Research progress of the serine synthesis pathway in pan-cancer The transcriptional expression differences of key enzymes in the de novo serine synthesis pathway (including PHGDH, PSAT1 and PSPH) across pan-cancer specimens were systematically analyzed using the Timer online database ( Figure 2 ), revealing the expression heterogeneity and potential tumor-specific expression patterns of these enzymes in distinct cancer types

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Although vitamin K has a low potential for toxicity, it can interact with certain medications, such as warfarin and antibiotics ( SUMMARY Both water- and fat-soluble vitamins can cause side effects when taken in high doses, with some causing more severe symptoms than others

Biomed Pharmacother = Biomed Pharmacotherapie (2018) 106:1098107

The lipid peroxidation is a free radical-driven reaction that primarily affects polyunsaturated fatty acids (PUFAs) in cell membranes, the product of which gradually increases during the ferroptotic cell death, from the initial lipid hydroperoxides (LOOHs) to the later production of malondialdehyde (MDA) and 4-hydroxynenoal (Kagan et al., 2017)