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2015;26(5):e4226

That is why the transdermal administration of cannabinoids would have some advantages: the possibility to increase the therapeutic dose by avoiding the hepatic first-pass effect

Katzenstein AL, Bloor CM, Leibow AA

31 Rondanelli et al found that, compared to placebo capsules, administering a formulation containing melatonin, magnesium, and zinc to 43 elderly subjects with primary insomnia, one hour before bedtime over an 8-week period, enhanced sleep quality and increased the total sleep time as measured by wearable arm sensors