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Their integration with systemic TB therapy requires consideration of drugdrug interactions, additive toxicity, and potential synergistic effects (Sieniawska et al., 2018)

They contain DNA fragments, mRNAs and noncoding RNAs and serve as pivotal communicating messengers between cells in early stages of premetastatic niche formation and are critically associated with EMT and metastatic progress [73]

Upon binding in the nucleus to specific DNA-sequences the receptor dimerizes with a second molecule and the homodimer entity recruits further additional proteins (e.g., coactivators, general transcription factors, RNA-polymerase II) via specific interaction motifs (29)