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The correct approach is modulation, not suppression

While often viewed as a last resort, insulin should be considered earlier due to its proven efficacy, ability to achieve remission [] , and consistent glycemic control, despite the risk of hypoglycemia being lower in T2DM than in T1DM

The temperature was kept at 300 K in all simulations using a velocity rescaling thermostat 36 , and the pressure was kept at 1 bar (using a Berendsen barostat 37 for the equilibration steps and a ParrinelloRahman barostat 38 for the production)