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Whether thats a dose issue, a formulation issue, the difficulty of controlling for diet and exercise, or a ceiling on what this mechanism can actually achieve in humans is still somewhat open

This cascade of oxidative damage to proteins, lipids, and DNA highlights the interconnected pathways through which NO affects neural integrity ( 6.2.2 Excitotoxicity NO acts as a noncompetitive inhibitor of NMDAR, disrupting their regulatory role in synaptic plasticity, memory, and learning (Wu et al., 2021)

Brain 142 , 32803293 (2019)

Discussion In this study, 12 weeks of taurine supplementation significantly improved insulin sensitivity and lowered serum glucose and serum lipid concentrations in diabetic OLETF rats that were 50 weeks old at the beginning of supplementation

116 Diagnostic approaches for CAN include HRV tests such as the deep breathing test, valsalva maneuver, and orthostatic testing, along with ambulatory blood pressure monitoring to identify irregular circadian blood pressure patterns