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While nanoparticles with smaller diameters are typically more efficient in entering the lymphatic vessels and reaching the lymph nodes

Zheng S, Deng Z, Chen F, Zheng L, Pan Y, Xing Q, et al

In a randomized, double-blind, placebo-controlled study, 93 subjects with colorectal polyps and 86 healthy subjects were given a placebo, folic acid (400 or 1,200 g/day), or folic acid (400 g/day) plus riboflavin (5 mg/day) for 45 days

For example, an early single-cell study profiled leukocytes from mouse hearts after MI and discovered a distinct subpopulation of cardiac macrophages that mounted a robust type I interferon response, driven by the transcription factor interferon regulatory factor 3 (IRF3)

Int J Mol Sci (2012) 13:954575