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Levels can be increased by systemic administration and concentrate in the seminal plasma, where it can produce its physiologic and therapeutic roles

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In some cases, increased vitamin C can result in kidney stones or even hemodialysis in people who are G6PD-deficient (a disease in which some drugs cause red blood cells to break down)

Tissues rely on highly coordinated communication between cells, structural proteins and signalling molecules to maintain organisation and adapt to changing physiological conditions