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Identification of metabolites was performed based on retention time and exact precursor ion m/z in previously established authentic standard-based in-house library (Kang et al ., 2021)

coi1-1 and coi1-2 mutant lines at Col-0 background were obtained from The Nottingham Arabidopsis Stock Centre (NASC, Nottingham, UK, N68754 and N68755)

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These findings were confirmed in primary hepatocytes taken from mice lacking MPC2 in the liver ( Mpc2 LKO ), when compared to cells from mice with an intact allele ( Mpc2 fl/fl )

This paper uses mitochondria-targeted catalase to modulate mitochondrial H 2 O 2 levels and, thereby, impact the lifespan in mice