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Zhang Y, Vasheghani F, hua LY, et al

Reproducing human and cross-species drug toxicities using a Liver-Chip

46 showed that a preserved responsiveness to the endothelium-dependent vasodilator acetylcholine, administered intracoronarily, is associated with a significantly lower incidence of cardiovascular events defined as a composite end point, including cardiovascular death, unstable angina, myocardial infarction, coronary revascularization, ischemic stroke and peripheral artery revascularization