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Blood Cancer 57 (7), 11471153

It also suppresses p38 MAPK signaling, another pathway involved in cellular stress responses

Moreover, the gene expression profile of antioxidant enzymes showed a significant increase in SOD and CAT via the dermal route and GR and GPx via the subcutaneous route [99]

The Link Between NSAIDs and Oxidative Stress While NSAIDs are widely used to manage pain and inflammation, emerging research suggests that their long-term use may contribute to oxidative stress, a condition in which free radicals overwhelm the body's antioxidant defenses