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Prostate cancer cells can release mediators that change the balance between osteoblast and osteoclast activities, leading to osteoblastic metastases

TIM-3 is expressed on the surface of innate immune cells, including dendritic cells (DCs), monocytes, macrophages 27,52,53,54 and natural killer cells (NK) 26,28

Mycol 62, myae083

The closest FDA-approved IGF-1 product is mecasermin (Increlex) , native recombinant human IGF-1, approved only for the long-term treatment of growth failure in pediatric patients with severe primary IGF-1 deficiency or GH gene deletion with neutralizing antibodies

Donors were informed about the study and gave a written consent prior blood donation for the study