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In macrophages and monocytes, lactate binds to GPR81 and reduces the effects induced by TLR4 agonists such as NF-B activation, the release of IL-1, and cleavage of CASP1, via ARRB2 (115) ( Table 1 )

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DHA treatment significantly reduces miR-21 expression in MCF-7 breast cancer cells while enhancing exosomal packaging of miR-23b, miR-27b, miR-320b, and let-7a (Figure 4)