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In acute myeloid leukemia, Elesclomol-Cu demonstrates concentration-dependent inhibitory effects on proliferation, which are associated with increased levels of reactive oxygen species and reduced glutathione

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The GPX3 forms proteinprotein interactions including GPX3GSTM3 interaction, GPX3GSTM2 interaction, GPX3INS interaction, GPX3PRDX2 interaction, GPX3PRDX1 interaction, and GPX3PRDX6 interaction apart from the TNFGPX3 interaction at high confidence scores (0.7 or 70%) (Figure 3

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