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Artesunate can be used to treat malaria and is derived from artemisinin, which is one of the main components of the herbal medicine Artemisia annua (Mancuso et al., 2021)

Therefore, taken together, these limitations reflect the need for developing a more accessible and simpler assay that can measure the rate of NADPH consumption by a specific pathway, such as the one mediated by glutathione-disulfide reductase (GSR)

Additionally, hypermethylation of the Foxp3 gene promoter in T cells results in reduced Foxp3 expression, impairing Treg cell function and disrupting immune homeostasis, thereby exacerbating MS progression (83, 85)