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Ethics declarations Competing interests KGW and VJNB are co-founders and shareholders of Aprea Therapeutics AB, a company that develops novel p53-based cancer therapy

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The CB2 receptor (CB2R) agonist AM1241, an anti-neuroinflammatory compound, modulates the NLRP3 inflammasome and AMP-activated protein kinase (AMPK) signaling pathways to suppress microglial overactivation, thereby reducing seizure frequency and alleviating depressive-like symptoms (Cai et al., 2024)