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Ferreiro E, Oliveira CR, Pereira C

Two notable proteins produced by SARS-CoV-2 are the spike, which is expressed on the virus envelope for attachment to receptors on host cells, and the RNA-dependent RNA polymerase (RdRp), which is required for replication of the virus ~30,000 nucleotide RNA genome [1]

2011 Nov;14(6):562-8

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An in vitro study of human bronchial epithelial cells from patients with COPD or asthma showed that increased oxidant burden may lead to reduced corticosteroid responsiveness in airway epithelium, with important consequences for the integrity of the epithelial barrier and associated production of pro-inflammatory cytokines [43]