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The organic phase was combined, washed with saturated brine, dried over anhydrous sodium sulfate, filter over a silica gel column (dichloromethane: methanol, 10:1) and eluted to get the intermediate ( S )-4, enantiomeric excess (ee) determined by HPLC, 98% ee

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Encouraging results have also been reported with mazdutide (LY3305677) in terms of BW, blood pressure (BP), glucose and lipid lowering 47 , and efinopegdutide (MK-6024) in terms of liver fat content in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) with or without T2D 48