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In explaining the reason for the different results in the two groups of chronic migraine and episodic migraine, we can pay attention to the results of the study performed by Yong et al

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Published in vitro work has characterized 5-Amino-1MQ as a competitive NNMT inhibitor with low micromolar potency against the recombinant enzyme, and as a cell-permeable agent that suppresses NNMT activity in cultured 3T3-L1 adipocytes at micromolar concentrations [1]

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