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Supporting this model, transcriptomic analysis of 3xTg-AD mice at different disease stages (2, 10, and 20 months) revealed age-related increases in DAM-associated genes such as Trem2, Tyrobp, Clec7a , and Cd68 , particularly in aged AD mice compared to young AD mice and aged-wild-type controls (Lambracht-Washington et al., 2023)

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10.1007/s00204-017-2036-4 Arch

Rowley M, Ohashi A, Mondal G, Mills L, Yang L, Zhang LZ, et al

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