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Oral amycretin showed up to 10.1% weight loss Evidence level: Low-moderate -- early-phase data with Lancet publication, impressive trajectories, but small samples and short duration

While anyone can develop B12 deficiency, certain groups are more vulnerable: Vegetarians and vegans Adults over 50 Individuals with gastrointestinal disorders People taking long-term acid-reducing medications Those who have undergone gastric surgery According to the National Center for Biotechnology Information, vitamin B12 deficiency can result from both dietary insufficiency and impaired absorption, particularly in individuals with underlying gastrointestinal conditions

Kuper H, Adami HO, Trichopoulos D

[1] In adults with confirmed GH deficiency, sermorelin may also be considered as a treatment option, although its use in healthy older adults for anti-aging purposes remains unproven and is not an FDA-approved indication

Thiamine in the treatment of wernicke encephalopathy in patients with alcohol use disorders