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In vivo , 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mice exhibited a marked reduction in tyrosine hydroxylase (TH)-positive neurons and CD31 expression, along with significant decreases in GSH and GPX4 levels

For example, in hepatocellular carcinoma cells, the metabolic enzyme PCK1 (cytosolic phosphoenolpyruvate carboxykinase 1) is endowed with a nonmetabolic enzyme function, which promotes the activation of the SREBP (sterol regulatory element-binding proteins) signaling pathway and enhances lipid droplet synthesis in tumor cells [38]

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The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and 3-AR knock-out mice