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Patients with Known or Suspected Mitochondrial Disease Depakote Sprinkle Capsules is contraindicated in patients known to have mitochondrial disorders caused by POLG mutations and children under two years of age who are clinically suspected of having a mitochondrial disorder [see Contraindications (4)]

doi: 10.1016/j.jtemb.2018.02.024 113 StoneJR

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Methionine also serves as a precursor to glutathione, one of the bodys most powerful antioxidants, helping protect cells from oxidative stress

Thus, bioactive nutrients that activate Nrf2 could reduce persistent OxS as well as help in functional optimization of viral-hijacked serine proteases and reset HMRD in PASC patients 70