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Where the targeting molecule and the effector molecule are polypeptides, the linkers may be joined to the constituent amino acids through their side groups (e.g., through a disulfide linkage to cysteine)

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2 Highlights of illustrative case This case is presented as an illustrative demonstration of how the multi-omic workflow operates in practice

Based on preclinical data demonstrating substantial MPNST shrinkage in mice treated with a combination of MEK and mTOR inhibitors, SARC031 is a trial of the MEK inhibitor selumetinib in combination with the mTOR inhibitor sirolimus for patients with unresectable or metastatic MPNST

doi: 10.1200/JCO.2006.06.9591 28 KoinisFNintosGGeorgouliasVKotsakisA