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3.2.3 Oxidative stress triggers and amplifies the chronic inflammatory response When SUA-induced metabolic stress and oxidative stress are sustained, the inflammatory response is consequently triggered and exacerbated

517 However, PERK heterozygous deficiency exacerbates IFN-induced apoptosis of remyelinating oligodendrocytes and impairs remyelination in cuprizone-induced demyelinated lesions

Schiavano, G.F

Trichurissuis infection alters the abundance of Proteobacteria and Deferribacteres in porcine colon microbiota [47] and increases the abundance of lactobacilli and decreases the diversity of the murine intestinal microbiota [48]

Pekna has been supported by grants from Swedish Research Council (2024-02814), the Swedish state under the agreement between the Swedish government and the county councils, the ALF agreement (1005387), The Swedish Brain Foundation (FO2023-0157) and The Swedish Stroke Foundation