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Description

Curr Biol 30:R1292R1297

The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic

Because CHAC1-mediated degradation of glutathione enhances necroptosis and ferroptosis, which are previously identified mechanisms of cell death (12), it is considered that CHAC1 has important roles in cell death