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7.2 Intestinal barrier disruption and initiation of the toxic cascade Available studies indicate that the gut serves as the first line of defense against toxins

One signal initiates repair sequences, hormonal responses, or gene expression changesamplifying initial input into broad systemic effects

After incubation with increasing concentrations of UA, the expression of GCL in the macrophage cell line elevated in a concentration-dependent manner

Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2