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JPH-203, a LAT1-specific inhibitor designed based on LAT1 ligands, has a strong affinity and does not show obvious toxicity in preclinical studies

Lyme disease is a chronic disease that is transmitted to humans when infected black legged ticks (known as deer ticks) bite the skin and subsequently embed themselves

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However, unlike mGluR5 in Group I, activation of mGluR7 in Group III reduced NMDA-mediated currents and NR1 surface expression in rodent basal forebrain cholinergic neurons through the regulatory mechanism of cofilin (CFL)

Purified GSTP1 associates with the MCF7 plasma-membrane enriched fraction Next, experiments were designed to determine if palmitoylation influences the ability of GSTP1 to associate with cellular membranes