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In the tooth loss model, serum metabolomics identified L-Asparagine as a key gut-derived metabolite that accumulated systemically and thereby further substantiating the mechanistic link along the oralgutbrain axis in vitro study ( Prevotella and Bacteroides species (Yan et al., 2024)

In a rat model of rheumatoid arthritis, oral Centella asiatica methanol fraction (50250 mg/kg/day for 15 days) significantly reduced joint swelling and synovial inflammation

Mil Med Res 9(1):26 Guo Q, Yin M, Fan J, Yang Y, Liu T, Qian H, Dai X, Wang X (2022b) Peroxidase-mimicking TA-VOx nanobranches for enhanced photothermal/chemodynamic therapy of glioma by inhibiting the expression of HSP60

Immune cells and their interactions with intestinal cells are also important pro-fibrotic factors

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