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Acknowledgments We thank Dalian Medical University, the Second Affiliated Hospital of Dalian Medical University, the Science and Technology Program of Liaoning Province, and Editage for the support of this article

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TL-895, a Highly Selective, Covalent Inhibitor of Brutons Tyrosine Kinase (BTK), Sensitizes Myeloproliferative Neoplasm (MPN)-Blast Phase Stem Cells to Navtemadlin By Targeting Intrinsic Dysregulated MDM2/p53 and NF-b Pathways and Disrupting the Protective Tumor Microenvironment (TME)

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Chronic stress in mice has also been linked to a reduction in adult neurogenesis in the dentate gyrus (GD), the main region where new neurons are generated throughout life [75-77] that may be missing in the CA1 area of the hippocampus [78,79]