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Considerations for Linker Design of drug conjugates Drug Conjugate Linkers Effect on the PK, Efficacy, and Toxicity Profiles Hydrophilicity is crucial for the development of antibody-drug conjugates, and low hydrophilicity of the linker can cause many problems, such as low coupling efficiency, deposition of ADCs in plasma, and non-specific uptake of ADCs in tissues, and so on

Information about the research is sent to all schools located in the recruiting areas, inviting them to participate with instructions on how to contact the research team if they would like further information, have any questions, or would like to express interest

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A., Kobe B., et al