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Peer review Peer review information Nature Cancer thanks Dmitri Simberg and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

This similar observation (more deposition with a linear GBCA) was made by Gibby et al

IV vitamin treatment is effective for those with vitamin or mineral deficiencies and provides many benefits

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Notably, we have demonstrated in an HD mouse model that mitochondrial dysfunction leads to enhanced release of mtDNA into the cytosol, which primes innate immune activation via the cGASSTING pathway