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Furthermore, GSH is necessary to maintain GPX4 activity

The frequency of glutathione IV therapy depends on individual health goals and conditions

P., Van Pelt, J

The underlying mechanism is as follows: oxidative phosphorylation, the TCA cycle, and the electron transport chain face inhibition due to an inadequate oxygen supply to brain tissue, alongside mitochondrial damage and dysfunction, leading to a marked decrease in ATP synthesis and overall energy metabolism impairment