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Danik et al., 2013

RNase-free water and TPCK-trypsin were purchased from Thermo Fisher Scientific (UK)

Dissolve Epithalon powder in Sterile Water for Injection (SWFI) or Bacteriostatic Water (BAC) per your protocol, then store reconstituted solution at 28 C for up to 7 days

Bispecific antibodies may also provide an effective treatment for solid tumours non-respondent to available monoclonal antibodies such as the commercial anti-epidermal growth factor receptor (EGFR) antibody cetuximab that shows no efficacy as a monotherapy in BRAF -mutated colorectal cancer 24

In cirrhotic patients, nociceptive pain arises from various sources such as pathological fractures, ascites, splenomegaly, muscle cramps, musculoskeletal diseases like avascular necrosis and septic arthritis, and mastalgia ( Neuropathic pain, stemming from lesions or maladies afflicting the somatosensory nervous system, precipitates aberrant sensory processing within the brain and spinal cord