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PMID: 41931110 Bioconjug Chem Development of a Long-Acting and Stapled Dual Amylin and Calcitonin Receptor Agonist as Monotherapy and Combination with GLP-1R Agonists for the Treatment of Obesity

What is Fragment 176-191

B12 primarily supports energy metabolism and nerve health

Its also required for your nerve cells to function normally

This remarkable selectivity stems from 5-amino-1MQs specific interaction with the nicotinamide-binding pocket of NNMT, rather than the SAM-binding site common to many methyltransferases