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This characteristic has been implicated in the intrinsic resistance of NTHi to siderophore-targeting compounds observed in vivo

[DOI] [PMC free article] [PubMed] [Google Scholar] 58.American Diabetes Association

It has been demonstrated that dendritic cells downregulate CD80 expression, preventing T cell activation via CD28, and exhibit high amounts of PD-L1

Liposomal encapsulation significantly enhanced transdermal delivery and barrier recovery, suggesting potential benefits in terms of stability, permeability, and immune modulation (Kim et al., 2015)

In addition, UM4118, a nanomolar-active analog of S767, was identified as exhibiting copper-specific ionophore activity