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Conversely, transcriptional repression is mediated by corepressors such as nuclear receptor corepressor (NCoR) and silencing mediator of retinoid and thyroid hormone receptors (SMRT)

Patients without prior daratumumab exposure achieved a 60% ORR ( n = 40) [58]

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In addition, the feasibility of PRIT as a CD38-based therapy was confirmed in murine models with excellent tumor-to-normal organ ratios of absorbed dose [129]