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The significance of certain epidemiological observations with respect thereto

The role of iron in anthracycline cardiotoxicity

We further demonstrated that an increase in urinary GSH concentrations during the formation of TLS is a common phenomenon in both mice and humans and proposed the utility of urinary GSH as a biomarker to detect TLS in the kidney

Among tyrosine kinase inhibitors, imatinib (a PDGFR inhibitor) and erlotinib (an EGFR inhibitor) induce ROS-dependent apoptosis in melanoma and non-small-cell lung cancer cells, respectively, through disruption of mitochondrial membrane potential upon the stimulation of JNK and p38 phosphorylation 88,89 , while vemurafenib (a BRAF inhibitor) increases the production of superoxide anions with the commensurate depolarization of the mitochondrial membranes in melanoma cells 90

At 6 weeks of age, mice were housed in plastic cages and received standard chow (AIN-76) and water ad libitum prior to experiment maintained on a 12 h/12 h light/dark cycle