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Notably, emerging evidence reveals that HIF-1 transcriptionally activates heat shock factor 1 (HSF1), the master regulator of the heat shock response [56, 57]

4.1 Alkaloids 4.1.1 Berberine Berberine (BBR), extracted from the rhizomacoptidis, possesses multi-pharmacological effects, including antioxidative effects, reduction of mitochondrial injury, anti-inflammatory actions, autophagy regulation, and cell death (Rui et al., 2022)

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