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What is not known is whether this distortion is reversible or is sufficient to cause irreversible structural changes to the brain that may potentially lead to a loss of biological information

Compared to mice with a global alcohol dehydrogenase 2 gene knockout ( Aldh2) , which exhibit remarkably higher blood acetaldehyde concentrations following acute oral alcohol administration than wild-type controls, mice with hepatocyte-specific Aldh2 deletion showed only about a 50% increase in systemic acetaldehyde (123)

Some mtDNA regions are more prone to mutations, particularly in genes encoding respiratory complex components

(2017) 20:S7693

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