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Few studies have examined associations between TMAO, MedDiet, and gut microbiome composition

In addition to participating in ubiquitin-dependent mitophagy, some mitochondrial proteins also act as mitophagy receptors, directly mediating the targeted binding and degradation process of dysfunctional mitochondria to autophagosomes (Figure 2f) (Table 1)

In wildtype mice, optogenetic inhibition of GABAergic interneurons in the medial prefrontal cortex (mPFC) leads to cognitive deficits ( +/ ) or absent (PV / ) expression exhibit the core ASD-like symptoms ( In addition, Reelin is an extracellular matrix glycoprotein closely related to neural development, which is involved in the regulation of neuronal migration, synaptic plasticity and neural network formation ( 3.2 The relationship between GABAergic signaling pathway abnormalities and ASD 3.2.1 The synthesis, release, transport, and metabolism of GABA The biosynthesis of GABA primarily relies on the decarboxylation of glutamate catalyzed by GAD

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doi: 10.1186/s13063-018-3076-7 62 RechJTascilarKHagenMKleyerAMangerBSchoenauVet al