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Finnell JE, Lombard CM, Padi AR, Moffitt CM, Wilson LB, Wood CS, et al

LDN is an immune-modulator that decreases the number of TH1 cells and TH17 cells results in immunebalance with the regulation of cytokines release [36]

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Cross-cancer comparisons reveal that although the SSP serves conserved functions in sustaining one-carbon unit supply and mediating therapeutic resistance across cancer types, the remarkable heterogeneity of its upstream regulatory mechanismsincluding Kras/FGFR3 mutations, MYC-mediated stemness maintenance, and m6A epigenetic modificationsdictates that therapeutic strategies must be precisely tailored