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Profound differences in expression of selected genes were observed in overweight and obese PCOS females compared to normal and underweight PCOS females

Emerging research directions include investigation of senescence heterogeneity and tissue-specific senescent cell populations, with FOXO4-DRI serving as a tool for studying how different senescent cell types contribute to various pathological processes

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dose-dependent GI adverse events (nausea, vomiting) similar to other amylin analogues Exposure: Dose-proportional increases in Cmax and AUC Gastric Effects: Dose-dependent slowing of gastric emptying confirmed via paracetamol absorption test Appetite Suppression: Reduced ad libitum food intake at doses 1.2 mg Clinical Significance: Established feasibility of once-weekly dosing and identified dose range for Phase 2 studies