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NNMT inhibition increases NAD+ availability, which is known to support mitochondrial function, reduce fibrosis, and lower inflammation

- Cardiac glycosides: May increase the possibility of arrhythmias or increase digitalis toxicity associated with hypokalemia

5 Yang, W., Cai, X., Wu, H

doi: 10.1016/j.celrep.2021.108771 Summary Keywords childhood cancer, neuroblastoma, combination therapy, oxidative stress, DPI, MitoQ, metabolism Citation Epp S, Egan D, Poon E, Abdul Aziz AA, Wynne K, Chesler L, Halasz M and Kolch W (2025) Oxphos targeting of MYCN -amplified neuroblastoma

Semaglutide is a prescription medication with clear indications and monitoring needs, so your provider should review your full plan, medications, and tolerability