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Published 2021 Nov 12

Fatty acid metabolism in carriers of apolipoprotein E epsilon 4 allele: Is it contributing to higher risk of cognitive decline and coronary heart disease

Domen S, Domen HM

RNS not only directly oxidize and deplete GSH, but also downregulate SLC7A11 expression to restrict cystine uptake and inhibit glutathione reductase, thereby blocking GSH regeneration