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For people with major depressive disorder, a more severe form of depression, one study found that vitamin B12 supplements, along with antidepressants, greatly improved symptoms

Because they are naturally occurring sequences in the human body, they are generally well-tolerated with minimal documented toxicity

[63] In August 2022, a bivalent version of the vaccine (Pfizer-BioNTech COVID-19 Vaccine, Bivalent) was authorized for use as a booster dose in individuals aged twelve and older in the US

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